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Resident Evil Requiem Safe Combinations Guide

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Last updated: October 8, 2026 12:01 am
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  • The game features five safes in total. Three are in the Care Center, where your journey begins as Grace, and the other two are found later in the ARK’s final area. While notes containing combinations exist, you’re not required to find them first. Also, be aware that safe combinations swap out if you play on Insanity difficulty, adding a challenging layer to your resource gathering.
  • Care Center Bar & Lounge Safe
  • The second safe is tucked away in the Examination Room of the Care Center’s East Wing. While the note to this safe can be found near the Leas Researcher’s Office on the second-floor hallway, here are the combinations to save you the hassle:
  • The Care Center basement also houses a safe, located near the forklift in a small room that you get to by crawling through the vent from the workshop. Though Grace herself can’t find the combination note, Leon collects it during his segment just before this. To save a backtrack, here are the opening combinations:
  • Once you escape the Care Center and advance into the ARK, two more safes await during the game’s climax. Both combinations are conveniently located near nearby typewriters, so if you explore thoroughly, you can find them without a guess. Here’s the code for the safe inside the Sterilization Chamber:
  • The final safe is located in the Monitor Control Room. Most players will have grabbed its note just after the Sterilization Chamber, but if you want to get straight to unlocking, enter the following combinations:

In Resident Evil Requiem, resource scarcity forces players to seek out every possible advantage, and safes scattered throughout the game hold crucial items and antique coins. These safes stand as small but significant barriers to survival, each demanding its own combination to unlock. Knowing these codes upfront can mean the difference between scrounging for supplies or wasting precious time hunting down clues, especially if you’re pushing for the “No Safe is Safe” trophy or speeding through a New Game Plus run.

The game features five safes in total. Three are in the Care Center, where your journey begins as Grace, and the other two are found later in the ARK’s final area. While notes containing combinations exist, you’re not required to find them first. Also, be aware that safe combinations swap out if you play on Insanity difficulty, adding a challenging layer to your resource gathering.

The first safe you’ll encounter sits on the second floor of the Care Center’s West Wing, inside the Bar & Lounge. Normally, you’d have to locate a note in the nearby office to get the combination, but if you want to cut straight to the chase, the codes go as follows:

Care Center Bar & Lounge Safe

The first safe you’ll encounter in the game is located on the second floor of the Care Center’s West Wing, in a room called the Bar & Lounge. In order to find the combination though, you’ll need to wait until you can access the office on the same floor and pick up a note on a desk there. If you just want to open the safe now though, here are the combinations

For Normal difficulty: Left 10 – Right 80 – Left 30

On Insanity difficulty, the combination shifts to: Right 20 – Left 50 – Right 30

The second safe is tucked away in the Examination Room of the Care Center’s East Wing. While the note to this safe can be found near the Leas Researcher’s Office on the second-floor hallway, here are the combinations to save you the hassle:

This second safe is located in the Examination Room in the Care Center’s East Wing. To find the note containing the combination make your way to the second floor hallway by the Leas Researcher’s Office. As for the combinations:

Normal difficulty code: Right 30 – Left 10 – Right 50

Insanity difficulty code: Left 50 – Right 30 – Left 90

The Care Center basement also houses a safe, located near the forklift in a small room that you get to by crawling through the vent from the workshop. Though Grace herself can’t find the combination note, Leon collects it during his segment just before this. To save a backtrack, here are the opening combinations:

The basement are you’ll be taking a short detour to during the story also has a safe within it. It is located in a small room near the forklift after you crawl through the vent from the workshop. As for the combination, you cannot find it as Grace but you CAN find it as Leon in the segment before this. In case you someone missed that note, here are the answers:

Normal difficulty: Right 60 – Left 40 – Right 80

Insanity mode: Left 70 – Right 50 – Left 20

Once you escape the Care Center and advance into the ARK, two more safes await during the game’s climax. Both combinations are conveniently located near nearby typewriters, so if you explore thoroughly, you can find them without a guess. Here’s the code for the safe inside the Sterilization Chamber:

After you leave the Care Center, you won’t find another safe until the final hours of the game as Grace and Leon infiltrate the ARK. This area contains two safes, whose combinations you’ll find near the area’s typewriters. As for which is which, here is the combination for the one in the Sterilization Chamber:

Normal difficulty combination: Right 10 – Left 90 – Right 20

Insanity difficulty combo: Left 80 – Right 50 – Left 0

The final safe is located in the Monitor Control Room. Most players will have grabbed its note just after the Sterilization Chamber, but if you want to get straight to unlocking, enter the following combinations:

Only one safe left! Make your way down to the Monitor Control Room where you will find this safe. More likely than not you picked up this safe’s note right after the other one, time to input combinations one last time.

Normal difficulty: Left 50 – Right 60 – Left 80

On Insanity, the numbers change to: Right 20 – Left 0 – Right 70

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